Proof of prior coronary heart failure acquired from outpatient or secondary healthcare facility diagnoses in advance of start of NSAID treatment. P values take a look at homogeneity of odds ratios concerning groups. NA=not accessible
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We outlined the day of the very first admission for heart failure recognized all through observe-up as the index date. Codes accustomed to identify coronary heart failure cases in Every single databases are reported inside the supplementary content (table S1).
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Our study experienced some limitations. For starters, our study may not have captured all NSAID exposure, for the reason that Some medicines (eg, ibuprofen) are also available around the counter in many of the four nations around the world. As a result, individuals labeled as non-recent customers of NSAIDs Within this study may even have been existing customers of over the counter NSAIDs.
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For every cohort member, we directly calculated the period protected by the availability of each and every specific NSAID from the prescribed day by day dose, if readily available (that is, PHARMO and Skinny databases), or by dividing the entire level of drug prescribed with the described day-to-day dose.
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